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Effects of Jobelyn on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice.

AUTHORS:

 Stephen Asehinde Abayomi Ajayi Adewale Bakre Osarume Omorogbe Adaeze Adebesin Solomon Umukoro

Basic Clin Neurosci 2018 Nov-Dec;9(6):389-396. Epub 2018 Nov 3.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs. The current study aimed at ascertaining the effect of Jobelyn (JB), an African dietary supplement, on seizures, altered oxidative stress, and glutamate decarboxylase activity induced by isoniazid in mice.

Methods: A total of 6 mice received JB (10-50 mg/kg, PO), pyridoxine (300 mg/kg), diazepam (5 mg/kg), or distilled water (10 mL/kg) 30 minutes prior to the induction of SE with injection of isoniazid (300 mg/kg, IP). Read More

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 November 2018

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Jobelyn Attenuates Oxidative Stress and Improves Memory Performance in Mice Exposed to Anoxic Stress.

AUTHORS:

 Osarume Omorogbe

Drug Res (Stuttg) 2019 May 10;69(5):291-296. Epub 2018 Dec 10.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.

Objective: Chronic stress impairs memory by damaging brain cells via induction of oxidative stress. Hence, the use of agents with antioxidant activity is being investigated as potential drugs against chronic stress-induced memory decline. This study evaluated the effect of Jobelyn (JB), a potent antioxidant food supplement on memory deficit induced by anoxic stress in mice and on brain levels of biomarkers of oxidative stress. Read More

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 May 2019

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Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway.

AUTHORS:

 Solomon Umukoro Ejiroghene E Oghwere Benneth Ben-Azu Olatunde Owoeye Abayomi M Ajayi Osarume Omorogbe Olajuwon Okubena

Pathophysiology 2019 Mar 28;26(1):77-88. Epub 2018 Oct 28.

Health Forever Products Ltd., Ikeja, Lagos, Nigeria.

The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control received normal saline while groups 3-5 were given JB (25, 50 and 100 mg/kg, p.o) daily for 28 days. Read More

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 March 2019

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